HealthCheck USA herpes testing information

Received from them 9-6-2001

The IgG test that LabOne offers for HSV 1 and 2 is type-specific.
The test kit is manufactured by Focus. LabOne does not perform the test
in-house, but uses AML as the reference lab. Below is an example of the way
the IgG test is reported:

Herpes Simplex Virus 1,2 Type-Specific IgG Abs. 

HSV-1 IgG Antibodies 0.07 <0.90

HSV-2 IgG Antibodies 0.04 <0.90
Index Values for HSV-1 and HSV-2 IgG Antibodies:
<0.90 Negative
0.90-1.10 Equivocal
>1.10 Positive
This test distinguishes type-specific IgG
antibodies to recombinant G proteins of HSV-1 or 
HSV-2. It identifies prior infection but does not
indicate the site of infection. Total HSV IgG
antibodies may appear 8-12 weeks past primary
infection; type-specific antibodies may not
appear until 12-16 weeks after exposure,
particularly if antiviral therapy was used. If
primary infection is suspected, but a negative
initial serological result is obtained, then sub-
mission of a convalescent specimen, after an
additional 12-16 weeks, is recommended. 


The IgM test also is sent to AML. They use an IFA method; the kit is
manufactured by BION. In the past, AML used an EIA method, but the
manufacturer of the kit lost FDA approval. Here is an example of how the
IgM test currently is reported:

Herpes Simplex Virus (1,2) IgM Antibodies, Serum 
HSV-1 Antibodies <1:10 <1:10

HSV-2 Antibodies <1:10 <1:10
Type specific reactivities are measured and
reported separately; however, when interpreting
data, it should be noted that strong cross-
reactivity exists between HSV-1 and HSV-2.